Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC030
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-18 08:44
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 1/2+1/4+1/2+1/4 caps Madopar HBS 2 uvece pre spavanja

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 7, 'TN': 7, 'TP': 35, 'FP': 23}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 41, 'TN': 29, 'TP': 1, 'FP': 1}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 32, 'TN': 28, 'TP': 10, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 18, 'TN': 10, 'TP': 24, 'FP': 20}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.572
timePerCircleCoV 0.539502
timePerCircleSlope -0.149804
meanError 3.35162
tremorFreq 5.85938
tremorRelPower 30.1714
tremorGyroAmpMean 0.0189387
tremorGyroAmpSlope 0.000594291
tremorGyroAmpCoV 0.361329
tremorCoordAmpMean 0.0854545
tremorCoordAmpSlope 0.0229791
tremorCoordAmpCoV 1.88319
tremorAccAmpMean 0.0566584
tremorAccAmpSlope 0.00321947
tremorAccAmpCoV 0.170761
tremorPcRelVar 0.771608
tremorPcX 0.962568
tremorPcY 0.27104

Circle Segment 1

Duration 18.52 s, Accuracy Estimate 1.599 (lower is better)

Circle Segment 2

Duration 15.2 s, Accuracy Estimate 2.741 (lower is better)

Circle Segment 3

Duration 9.6 s, Accuracy Estimate 3.385 (lower is better)

Circle Segment 4

Duration 7.36 s, Accuracy Estimate 3.401 (lower is better)

Circle Segment 5

Duration 6.68 s, Accuracy Estimate 3.031 (lower is better)

Circle Segment 6

Duration 5.52 s, Accuracy Estimate 5.092 (lower is better)

Circle Segment 7

Duration 6.08 s, Accuracy Estimate 3.537 (lower is better)

Circle Segment 8

Duration 6.4 s, Accuracy Estimate 2.694 (lower is better)

Circle Segment 9

Duration 5.52 s, Accuracy Estimate 3.957 (lower is better)

Circle Segment 10

Duration 4.84 s, Accuracy Estimate 4.08 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 27.7
timePerSpiralCoV 0.285974
timePerSpiralSlope 0.112677
meanError 5.52699
tremorFreq 6.15234
tremorRelPower 31.909
tremorGyroAmpMean 0.023505
tremorGyroAmpSlope 0.000839944
tremorGyroAmpCoV 0.382328
tremorCoordAmpMean 0.0547859
tremorCoordAmpSlope -0.00133554
tremorCoordAmpCoV 0.762514
tremorAccAmpMean 0.0792575
tremorAccAmpSlope 2.69955e-05
tremorAccAmpCoV 0.137707
tremorPcRelVar 0.627754
tremorPcX -0.9993
tremorPcY -0.037422

Spiral Segment 1

Duration 23.48 s, Accuracy Estimate 2.41 (lower is better)

Spiral Segment 2

Duration 15.4 s, Accuracy Estimate 9.48 (lower is better)

Spiral Segment 3

Duration 27.4 s, Accuracy Estimate 6.792 (lower is better)

Spiral Segment 4

Duration 36.08 s, Accuracy Estimate 6.45 (lower is better)

Spiral Segment 5

Duration 27.52 s, Accuracy Estimate 2.441 (lower is better)

Spiral Segment 6

Duration 36.32 s, Accuracy Estimate 5.589 (lower is better)

Elel

eDurationMean 0.469333
eDurationStd 0.059578
eDurationStdnorm 0.126942
eDurationMedian 0.4775
eDurationQuartdelta 0.085
eDurationQuartdeltanorm 0.17801
eDurationKurt 2.66597
eDurationTrenddiff -0.07
eDurationTrendratio 0.86
eWidthMean 5.0427
eWidthStd 1.41783
eWidthStdnorm 0.281166
eWidthMedian 4.8555
eWidthQuartdelta 1.638
eWidthQuartdeltanorm 0.337349
eWidthKurt 5.83495
eWidthTrenddiff -0.351
eWidthTrendratio 0.930233
eHeightMean 9.0207
eHeightStd 2.37968
eHeightStdnorm 0.263802
eHeightMedian 9.009
eHeightQuartdelta 3.627
eHeightQuartdeltanorm 0.402597
eHeightKurt 3.46789
eHeightTrenddiff -2.808
eHeightTrendratio 0.710843
eAspectMean 0.567831
eAspectStd 0.103141
eAspectStdnorm 0.18164
eAspectMedian 0.556349
eAspectQuartdelta 0.145032
eAspectQuartdeltanorm 0.260685
eAspectKurt 1.97196
eAspectTrenddiff 0.117647
eAspectTrendratio 1.23529
eSlantMean 0.133164
eSlantStd 0.138402
eSlantStdnorm 1.03933
eSlantMedian 0.137669
eSlantQuartdelta 0.18759
eSlantQuartdeltanorm 1.36262
eSlantKurt 2.88318
eSlantTrenddiff 0.0287879
eRtopMean 0.747034
eRtopStd 0.108411
eRtopStdnorm 0.145122
eRtopMedian 0.747093
eRtopQuartdelta 0.166667
eRtopQuartdeltanorm 0.223087
eRtopKurt 2.38053
eRtopTrenddiff 0.0693767
eRbotMean 0.528312
eRbotStd 0.186965
eRbotStdnorm 0.353891
eRbotMedian 0.5
eRbotQuartdelta 0.180556
eRbotQuartdeltanorm 0.361111
eRbotKurt 5.81844
eRbotTrenddiff 0.0102041
eRrightMean 0.827812
eRrightStd 0.0875166
eRrightStdnorm 0.10572
eRrightMedian 0.841721
eRrightQuartdelta 0.141847
eRrightQuartdeltanorm 0.16852
eRrightKurt 2.61637
eRrightTrenddiff 0.0340293
eRleftMean 0.337688
eRleftStd 0.130008
eRleftStdnorm 0.384995
eRleftMedian 0.318588
eRleftQuartdelta 0.138923
eRleftQuartdeltanorm 0.436057
eRleftKurt 5.35321
eRleftTrenddiff 0.0121753
lDurationMean 0.531667
lDurationStd 0.107775
lDurationStdnorm 0.202712
lDurationMedian 0.515
lDurationQuartdelta 0.185
lDurationQuartdeltanorm 0.359223
lDurationKurt 2.12303
lDurationTrenddiff -0.13
lDurationTrendratio 0.783333
lWidthMean 6.03107
lWidthStd 1.49033
lWidthStdnorm 0.247109
lWidthMedian 6.1425
lWidthQuartdelta 2.34
lWidthQuartdeltanorm 0.380952
lWidthKurt 2.40797
lWidthTrenddiff -0.468
lWidthTrendratio 0.925926
lHeightMean 16.029
lHeightStd 1.97307
lHeightStdnorm 0.123094
lHeightMedian 15.8535
lHeightQuartdelta 2.691
lHeightQuartdeltanorm 0.169742
lHeightKurt 2.63711
lHeightTrenddiff -1.053
lHeightTrendratio 0.934783
lAspectMean 0.377524
lAspectStd 0.0866291
lAspectStdnorm 0.229466
lAspectMedian 0.368095
lAspectQuartdelta 0.145052
lAspectQuartdeltanorm 0.394063
lAspectKurt 1.96218
lAspectTrenddiff 0.0222215
lAspectTrendratio 1.06185
lSlantMean 0.138477
lSlantStd 0.112249
lSlantStdnorm 0.810595
lSlantMedian 0.127885
lSlantQuartdelta 0.172031
lSlantQuartdeltanorm 1.3452
lSlantKurt 1.95487
lSlantTrenddiff 0.0602038
lRtopMean 0.795846
lRtopStd 0.0874043
lRtopStdnorm 0.109826
lRtopMedian 0.822995
lRtopQuartdelta 0.143162
lRtopQuartdeltanorm 0.173953
lRtopKurt 2.2851
lRtopTrenddiff 0.0296896
lRbotMean 0.457434
lRbotStd 0.205564
lRbotStdnorm 0.449386
lRbotMedian 0.42449
lRbotQuartdelta 0.290043
lRbotQuartdeltanorm 0.683275
lRbotKurt 2.2795
lRbotTrenddiff -0.0936842
lRrightMean 0.852196
lRrightStd 0.0705954
lRrightStdnorm 0.0828393
lRrightMedian 0.869398
lRrightQuartdelta 0.0796675
lRrightQuartdeltanorm 0.0916353
lRrightKurt 3.76778
lRrightTrenddiff 0.0210164
lRleftMean 0.303303
lRleftStd 0.171337
lRleftStdnorm 0.564905
lRleftMedian 0.275995
lRleftQuartdelta 0.271997
lRleftQuartdeltanorm 0.985514
lRleftKurt 1.92991
lRleftTrenddiff -0.158434

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.978052
sumTouchScores 15.6488
meanMovementTime 1.031
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

FITTS Long Modified

meanTouchScore 0.634678
sumTouchScores 6.98146
meanMovementTime 1.491
numTouches 11
undershootPercentage 9.09091
overshootPercentage 45.4545

ZigZag

numZigzags 4
timePerZigzagMean 27.48
timePerZigzagCoV 0.15712
timePerZigzagSlope -0.0960699
meanError 2.13089
tremorFreq 5.56641
tremorRelPower 25.5563
tremorGyroAmpMean 0.0363458
tremorGyroAmpSlope 0.000703135
tremorGyroAmpCoV 0.379768
tremorCoordAmpMean 0.0834234
tremorCoordAmpSlope 0.0009213
tremorCoordAmpCoV 0.276883
tremorAccAmpMean 0.0814771
tremorAccAmpSlope 0.000198983
tremorAccAmpCoV 0.215941
tremorPcRelVar 0.756959
tremorPcX -0.646899
tremorPcY -0.762575

ZigZag Segment 1

Duration 33.52 s, Accuracy Estimate 2.067 (lower is better)

ZigZag Segment 2

Duration 27.08 s, Accuracy Estimate 2.229 (lower is better)

ZigZag Segment 3

Duration 23.36 s, Accuracy Estimate 2.418 (lower is better)

ZigZag Segment 4

Duration 25.96 s, Accuracy Estimate 1.81 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.728
timePerZigzagCoV 0.284098
timePerZigzagSlope -0.0775058
zigzagHeightMean 70.9419
zigzagHeightCoV 0.0262328
zigzagHeightSlope -0.00671783
meanError 0.0546359
tremorFreq 6.05469
tremorRelPower 28.2162
tremorGyroAmpMean 0.0552625
tremorGyroAmpSlope 0.00832863
tremorGyroAmpCoV 0.398594
tremorCoordAmpMean 0.0999158
tremorCoordAmpSlope 0.00832088
tremorCoordAmpCoV 0.299054
tremorAccAmpMean 0.0864091
tremorAccAmpSlope 0.00654658
tremorAccAmpCoV 0.303163
tremorPcRelVar 0.798093
tremorPcX 0.553535
tremorPcY -0.832826

ZigZag Offset Segment 1

Duration 20.08 s, Accuracy Estimate 0.089 (lower is better)

ZigZag Offset Segment 2

Duration 11.76 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 10.2 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 4

Duration 11.92 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 5

Duration 14.68 s, Accuracy Estimate 0.051 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.69}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.7819075705491416}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8601252523276508}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6672511569026484}